期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 473, 期 -, 页码 215-220出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2018.10.055
关键词
Amyloid aggregates; Magnetoferritin; Ferritin; Interactions between amyloid and magnetic materials; Anti-amyloid effect; Disruption of amyloid
资金
- Slovak Scientific Grant Agency VEGA [2/0016/17, 2/0062/16]
- Slovak Research and Development Agency, Slovakia [APVV-015-0453, APVV SK-TW-2017-0012]
- European Fund of Regional Development [26210120012, 26220220186]
Presence of protein amyloid aggregates is associated with many neurodegenerative disorders, such as Alzheimer's disease etc. The effect of magnetoferritin and reconstructed ferritin on the structure of lysozyme amyloid aggregates was studied using small-angle X-ray scattering, atomic force microscopy and thioflavin T fluorescence measurements. It has been shown that both magnetoferritin and reconstructed ferritin molecules affect the size, structure and amount of the amyloid fibrils. We assume that the anti-amyloid effect of magnetoferritin and reconstructed ferritin is due to the presence of iron in solutions but is not associated with the magnetic character of the iron oxide phases, i.e. magnetite/maghemite for magnetoferritin and ferrihydrite for ferritin.
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