期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 106, 期 1, 页码 219-227出版社
WILEY
DOI: 10.1002/JLB.MR0818-319R
关键词
Alzheimer's disease; immunotherapy; microglia; neuroinflammation; phagocytosis; TREM2
资金
- NIH [RF1AG05148501]
- Cure Alzheimer's Fund
Microglia are resident M phi s of the CNS that play pleiotropic functions in brain development and homeostasis. Impaired microglial functions are thought to be involved in the onset and progression of various neurodevelopmental and neurodegenerative diseases. Thus, understanding microglia in these settings may indicate new approaches for therapeutic intervention. Here, we review recent evidence implicating microglia in Alzheimer's disease and discuss potential therapeutic strategies targeting microglia and their receptors in this disease.
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