Rapid Dilapidation of Alcohol Using Magnesium Oxide and Magnesium Aspartate based Nanostructures: A Raman Spectroscopic and Molecular Simulation Approach

Magnesium in the form of magnesium sulphate, magnesium oxide, magnesium hydroxide, and magnesium carbonate magnesium was conventionally in use as an effective antidepressant component. However, the concentration of these materials was high, varying from 150 to 500mg per day. In recent days, nano-formulation of drugs is of high great interest due to its higher performance compare to the bulk structure. In the present work, MgO nanoparticle of size less than 10nm have been synthesized by the wet chemical method with a sintering condition of 400 degrees C for 3h. Magnesium aspartate was prepared from aspartic acid by modifying the prepared MgO nanoparticles. In vitro ethanol dilapidation studies at a various time interval and molecular docking interaction studies of MgO and Magnesium aspartate with NMDA receptors confirm that, these nanostructures compounds are suggestible as supplements for magnesium deficient and alcohol-induced depression. [GRAPHICS] .