期刊
JOURNAL OF INNATE IMMUNITY
卷 11, 期 4, 页码 303-315出版社
KARGER
DOI: 10.1159/000496033
关键词
Human thrombospondin-1; Streptococcus pneumoniae; Staphylococcus aureus; Colonization; Dissemination
类别
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation): DFG [374031971]
A successful colonization of different compartments of the human host requires multifactorial contacts between bacterial surface proteins and host factors. Extracellular matrix proteins and matricellular proteins such as thrombospondin-1 play a pivotal role as adhesive substrates to ensure a strong interaction with pathobionts like the Gram-positive Streptococcus pneumoniae and Staphylococcus aureus. The human glycoprotein thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the bloodstream during bacteremia. Human platelets secrete thrombospondin-1, which is then acquired by invading pathogens to facilitate colonization and immune evasion. Gram-positive bacteria express a broad spectrum of surface-exposed proteins, some of which also recognize thrombospondin-1. This review highlights the importance of thrombospondin-1 as an adhesion substrate to facilitate colonization, and we summarize the variety of thrombospondin-1-binding proteins of S. pneumoniae and S. aureus. (C) 2019 The Author(s) Published by S. Karger AG, Basel
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