期刊
JOURNAL OF INFECTIOUS DISEASES
卷 219, 期 -, 页码 S46-S56出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiz044
关键词
influenza vaccination; shedding-transmission relationship; viral eco-evolutionary dynamics
资金
- Intramural Research Program of the Vaccine Research Center
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH)
- Bill and Melinda Gates Foundation [OPP1091919]
- RAPIDD program of the Science and Technology Directorate Department of Homeland Security and the Fogarty International Center, NIH
- James S. McDonnell Foundation 21st Century Science Initiative Collaborative Award in Understanding Dynamic and Multi-scale Systems
- Natural Sciences and Engineering Research Council of Canada
- Bill and Melinda Gates Foundation [OPP1091919] Funding Source: Bill and Melinda Gates Foundation
A universal influenza vaccine (UIV) could considerably alleviate the public health burden of both seasonal and pandemic influenza. Although significant progress has been achieved in clarifying basic immunology and virology relating to UIV, several important questions relating to the dynamics of infection, immunity, and pathogen evolution remain unsolved. In this study, we review these gaps, which span integrative levels, from cellular to global and timescales from molecular events to decades. We argue that they can be best addressed by a tight integration of empirical (laboratory, epidemiological) research and theory and suggest fruitful areas for this synthesis. In particular, quantifying natural and vaccinal limitations on viral transmission are central to this effort.
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