期刊
JOURNAL OF INFECTIOUS DISEASES
卷 220, 期 7, 页码 1099-1108出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiy704
关键词
vagina; coinfection; exfoliation; sialidase
资金
- Burroughs Wellcome Fund Preterm Birth Initiative
- National Institutes of Health [R01 AI114635, R01 AI127554, K01 DK110225-01A1]
- American Heart Association [12POST12050583, 14POST20020011]
- Chemistry-Biology Interface Graduate Program at the University of Delaware
- National Center for Research Resources Grant [C06 RR015502]
Background. Bacterial vaginosis (BV) is a common imbalance of the vaginal microbiota characterized by overgrowth of diverse Actinobacteria, Firmicutes, and Gram-negative anaerobes. Women with BV are at increased risk of secondary reproductive tract infections and adverse pregnancy outcomes. However, which specific bacteria cause clinical features of BV is unclear. Methods. We previously demonstrated that Gardnerella vaginalis could elicit many BV features in mice. In this study, we established a BV model in which we coinfected mice with G. vaginalis and another species commonly found in women with BV: Prevotella bivia. Results. This coinfection model recapitulates several aspects of human BV, including vaginal sialidase activity (a diagnostic BV feature independently associated with adverse outcomes), epithelial exfoliation, and ascending infection. It is notable that G. vaginalis facilitated uterine infection by P. bivia. Conclusions. Taken together, our model provides a framework for advancing our understanding of the role of individual or combinations of BV-associated bacteria in BV pathogenesis.
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