期刊
JOURNAL OF INFECTIOUS DISEASES
卷 219, 期 -, 页码 S88-S96出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiy745
关键词
universal influenza vaccine; antigen design; structure-based vaccine; protein engineering; nanoparticle; antigen display; mRNA vaccine; broadly neutralizing antibody
资金
- Intramural Research Programs of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Technological advances in immunology, protein design, and genetic delivery have unlocked new possibilities for vaccine concepts and delivery technologies that were previously inaccessible. These next-generation vaccine design efforts are particularly promising in their potential to provide solutions to challenging targets for which conventional approaches have proven ineffective-for example, a universal influenza vaccine. In this perspective, we discuss emerging approaches to vaccine design and engineering based on recent insights into immunology, structural biology, computational biology, and immunoengineering. We anticipate that these cutting-edge, interdisciplinary approaches will lead to breakthrough vaccine concepts for ever-evolving and (re) emerging influenza viruses, with important ramifications for global public health.
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