期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 74, 期 -, 页码 187-192出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2019.02.025
关键词
L-DNA duplex; Drug delivery; Doxorubicin; Anticancer therapy
资金
- KIST intramural research program through the National Research Foundation of Korea - Ministry of Science and ICT
- Pioneer Research Center Program through the National Research Foundation of Korea - Ministry of Science and ICT [2014M3C1A3054141]
Three dimensional DNA nanostructures are often limited in scalability due to low assembly yield at high concentrations, leaving themselves less suitable for industrial uses. To overcome this drawback, we here employed L-DNA duplex (L-ds) as a drug carrier. Due to its simple structure, L-ds can easily be prepared at micromolar concentrations without causing any considerable by-product, providing sufficient scalability for practical development. With sufficient cellular uptake efficiency in SCC7 cells and the tumor accumulation level in a SCC7-tumor xenograft mouse model, L-ds could well be utilized as a carrier for intracellular and tumor delivery of an anticancer agent, providing substantial cytotoxicity and inhibition of tumor growth, respectively. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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