期刊
JOURNAL OF IMMUNOLOGY
卷 202, 期 9, 页码 2747-2759出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1801632
关键词
-
类别
资金
- Canadian Institutes of Health Research [MOP77746, MOP86622]
- National Sciences and Engineering Research Council of Canada
- Alberta Innovates-Technology Futures (AITF) scholarship
- Clark H. Smith Brain Tumor Centre Graduate Scholarship
- AITF Graduate Scholarship
- Alberta Innovates Health Solutions Summer Studentship
Immune and metabolic pathways collectively influence host responses to microbial invaders, and mutations in one pathway frequently disrupt activity in another. We used the Drosophila melanogaster model to characterize metabolic homeostasis in flies with modified immune deficiency (IMD) pathway activity. The IMD pathway is very similar to the mammalian TNF-alpha pathway, a key regulator of vertebrate immunity and metabolism. We found that persistent activation of IMD resulted in hyperglycemia, depleted fat reserves, and developmental delays, implicating IMD in metabolic regulation. Consistent with this hypothesis, we found that imd mutants weigh more, are hyperlipidemic, and have impaired glucose tolerance. To test the importance of metabolic regulation for host responses to bacterial infection, we challenged insulin pathway mutants with lethal doses of several Drosophila pathogens. We found that loss-of-function mutations in the insulin pathway impacted host responses to infection in a manner that depends on the route of infection and the identity of the infectious microbe. Combined, our results support a role for coordinated regulation of immune and metabolic pathways in host containment of microbial invaders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据