期刊
AMINO ACIDS
卷 48, 期 4, 页码 915-928出版社
SPRINGER WIEN
DOI: 10.1007/s00726-016-2171-x
关键词
Amino acids; Cell growth; mTOR; Rag; Small GTPase
资金
- National Research Foundation of Korea [NRF-2015K2A1A2071035]
Rag small GTPases were identified as the sixth subfamily of Ras-related GTPases. Compelling evidence suggests that Rag heterodimer (RagA/B and RagC/D) plays an important role in amino acid signaling toward mechanistic target of rapamycin complex 1 (mTORC1), which is a central player in the control of cell growth in response to a variety of environmental cues, including growth factors, cellular energy/oxygen status, and amino acids. Upon amino acid stimulation, active Rag heterodimer (RagA/B-GTP-RagC/D-GDP) recruits mTORC1 to the lysosomal membrane where Rheb resides. In this review, we provide a current understanding on the amino acid-regulated cell growth control via Rag-mTORC1 with recently identified key players, including Ragulator, v-ATPase, and GATOR complexes. Moreover, the functions of Rag in physiological systems and in autophagy are discussed.
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