期刊
JOURNAL OF HUMAN HYPERTENSION
卷 33, 期 7, 页码 531-541出版社
SPRINGERNATURE
DOI: 10.1038/s41371-019-0187-x
关键词
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资金
- Natural Science Foundation of Guangdong Province [2015A030313660]
- Science and Technology Program of Guangzhou [201604020143, 201604020018, 201510010254, 201803040012]
- Medical Science and Technology Research Fund of Guangdong Province [B2018023]
- National Key Research and Development Program of China [2017FYC1307603, 2016YFC1301305]
- Science Technology Program of Guangdong Province [2014B020212008]
- National Natural Science Foundation of China [81300230]
The aim of this meta-analysis of longitudinal studies was to obtain a valid and cogent assessment of predictive value of central haemodynamic variables for cardiovascular outcomes and all-cause mortality. We searched for eligible articles using MEDLINE, CINAHL, EMBASE and Web of Science between 1 January 1969 and 31 December 2017. We finally included 24 prospective cohort studies, comprising 146,986 individuals for this analysis. Adjusted pooled hazard ratio of total cardiovascular events was 1.10 (95% confidence interval [CI] 1.04-1.16) for a 10 mmHg increase of central systolic pressure, 1.12 (95% CI 1.05-1.19) for a 10 mmHg increase of central pulse pressure and 1.18 (95% CI 1.09-1.27) for a 10% increase of central augmentation index. Furthermore, pooled hazard ratio of all-cause mortality was 1.22 (95% CI 1.14-1.31) for a 10 mmHg increase of central pulse pressure and 1.19 (95% CI 1.05-1.34) for a 10% increase of central augmentation index. Central haemodynamic variables are independent predictors of cardiovascular disease and all-cause mortality. This finding supports the notion that central pressure components and indices could be suitably implemented in clinical practice.
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