期刊
JOURNAL OF EXPERIMENTAL BOTANY
卷 70, 期 12, 页码 3035-3041出版社
OXFORD UNIV PRESS
DOI: 10.1093/jxb/erz123
关键词
Augmin complexes; katanin; microtubule nucleation; plant microtubules; gamma-tubulin ring complexes
资金
- National Science Foundation of China [31571378, 31501088]
- State Key Laboratory of Plant Genomics, China
Microtubule-dependent microtubule nucleation occurs on the lateral surface of pre-existing microtubules and provides a highly efficient means of amplifying their populations and reorganizing their architectures. The gamma-tubulin ring complex serves as the template to initiate nascent microtubule polymerization. Augmin, a hetero-octameric protein complex, acts as a recruiting factor to target the gamma-tubulin ring complex to pre-existing microtubules and trigger new microtubule growth. Although microtubule-dependent microtubule nucleation has been extensively studied in both animal and plant cells, it remains unclear how the augmin complex assembles in plant cells, especially in cell-cyclespecific and cell-type-specific manners, and how its spatial structure orchestrates the nucleation geometry. In this review, we summarize the advances in knowledge of augmin-dependent microtubule nucleation and the regulation of its geometry, and highlight recent findings and emerging questions concerning the role of the augmin complex in establishing microtubule arrays and the cell-cycle-specific composition of augmin in plant cells.
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