期刊
JOURNAL OF CYSTIC FIBROSIS
卷 18, 期 6, 页码 844-850出版社
ELSEVIER
DOI: 10.1016/j.jcf.2019.02.004
关键词
Cystic fibrosis; Viruses; Inflammation; Bacteria; Pathogens
资金
- National Institutes of Health (NIH) [HL116211]
- National Health and Medical Research Council [NHMRC1043768, NHMRC1000896, NHMRCAPP1025550]
- Cystic Fibrosis Foundation Fellowship Training Grant
- Indiana Physician Scientist Award (Eli Lilly)
- Royal Children's Hospital Cystic Fibrosis Research Trust
Background: Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of respiratory viruses on the development of airway disease is poorly understood. Methods: Infants with CF identified by newborn screening were enrolled prior to 4 months of age to participate in a prospective observational study at 4 centers. Clinical data were collected at clinic visits and weekly phone calls. Multiplex PCR assays were performed on nasopharyngeal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and a subset underwent pulmonary function testing. We present findings through 8.5 months of life. Results: Seventy infants were enrolled, mean age 3.1 +/- 0.8 months. Rhinovirus was the most prevalent virus (66%), followed by parainfluenza (19%), and coronavirus (16%). Participants had a median of 1.5 viral positive swabs (range 0-10). Past viral infection was associated with elevated neutrophil concentrations and bacterial isolates in BAL fluid, including recovery of classic CF bacterial pathogens. When antibiotics were prescribed for respiratory-related indications, viruses were identified in 52% of those instances. Conclusions: Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens. Early viral infections appear to contribute to initiation of lower airway inflammation in infants with CF. Antibiotics were commonly prescribed in the setting of a viral infection. Future investigations examining longitudinal relationships between viral infections, airway microbiome, and antibiotic use will allow us to elucidate the interplay between these factors in young children with CF. (C) 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据