期刊
JOURNAL OF CONTROLLED RELEASE
卷 295, 期 -, 页码 187-200出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2018.12.049
关键词
Epilepsy; Anxiety; Antiepileptics; Anxiolytics; Lipid-based nanosystems; Nasal/intranasal route
资金
- National Funds through the FCT - Fundacao para a Ciencia e a Tecnologia [UID/Multi/04546/2013]
- Fundação para a Ciência e a Tecnologia [UID/Multi/04546/2013] Funding Source: FCT
Epileptic seizures and anxiety crisis are severe conditions that require fast and effective treatment, targeting the brain. Current emergency antiepiletics and anxiolytics have limited brain bioavailability, following oral, intravenous or rectal administration. This relates with the limited extent at which these drugs bypass the blood brain barrier (BBB). Thereby, the development of strategies that significantly improve the brain bioavailability of these drugs, along with a simple and safe administration by patients, attenuating and/or preventing epileptic seizures or anxiety crisis, are still a major need. In this respect, the nasal/intranasal route has been suggested as a promising strategy for drug targeting to the brain, thus avoiding the BBB. Besides, the use of lipid-based nanosystems, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), liposomes, nanoemulsions and microemulsions, have been demonstrating high efficiency for nose-to-brain transport. This review highlights the potential of using lipid-based nanosystems in the management of epilepsy and anxiety, by means of the nasal/intranasal route. So far, the reported studies have shown promising results, being required more in vivo experiments to further advance for clinical trials. Furthermore, toxicological concerns related to the need of evaluate the impairment on the mucociliary clearance mechanism have been pointed.
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