期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 539, 期 -, 页码 351-360出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2018.12.086
关键词
Tubular scaffolds; Mechanical properties; Controlled release; Anticoagulation; Vascular tissue engineering
资金
- National Key Research and Development Program of China [2016YFC1100200]
- National Nature Science Foundation of China [31470941, 81501595]
- Youth Foundation of Zhongshan Hospital [2015ZSQN09]
- Talent Training Program Foundation for the Excellent Youth - Zhongshan Hospital [2017ZSYQ24]
- Innovation Fund of Zhongshan Hospital [2017ZSCX05]
Salvianic acid-loaded mesoporous silica nanoparticles into gelatin/polyurethane bilayered small-diameter tubular scaffold were prepared by thermally induced phase separation (TIPS) and electrospinning. Mesoporous silica nanoparticles (MSNs) were selected as carriers to load salvianic acid (SAL). The SAL-loaded MSNs (SAL@MSNs) with an optimized SAL loading efficiency of 10% was initially dispersed in gelatin solution and under a vacuum freeze-drying process as an inner layer of vascular scaffolds. Then, poly(ester-urethane)urea (C-PEEUU) nanofibers were electrospun outside the SAL@MSNs/Gelatin vascular scaffold to strengthen the spongy matrix. The loaded SAL within the MSNs/Gelatin/C-PEEUU bilayered small-diameter tubular scaffold showed a sustained release profile and good mechanical properties. In addition, the drug-loaded composite scaffold showed no unfavorable effects on the adhesion and proliferation of endothelial cells. Moreover, no intimal hyperplasia and acute thrombosis was observed in the short-term implantation in rabbit's carotid artery. We believe the SAL@MSNs/Gelatin/C-PEEUU bilayered vascular scaffolds have promise for vascular tissue engineering applications. (C) 2018 Elsevier Inc. All rights reserved.
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