期刊
JOURNAL OF CLUSTER SCIENCE
卷 30, 期 3, 页码 715-726出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10876-019-01530-x
关键词
Polyaniline-bimetal; Nanocomposite; Antibacterial activity; Clinical pathogens; Anticancer activity
资金
- University Grants Commission, New Delhi [F. 14-13/2013]
- DST-FIST [SR/FST/LSI-667/2016(C)]
- DST-PURSE [SR/PURSE Phase 2/38 (G)]
- MHRD-RUSA 2.0 [Policy (TNMulti-Gen), Dept. of Edn. Govt. of India] [F. 24/51/2014-U]
- UGC-BSR, New Delhi, India
This study gold (Au) and gold-platinum (Au-Pt) colloids were synthesized by borohydride reduction method in the presence of poly(N-vinyl-2-pyrrolidone) as a stabilizing agent. Besides, pristine polyaniline (PANI), PANI-Au nanocomposites, and PANI-Au-Pt nanocomposites were prepared. The synthesized nano-composites characterized by UV-Vis, FT-IR, XRD, and HR-TEM with energy dispersive X-ray techniques. Au and Au-Pt NPs were spherical in shape with particle sizes at 8 and 3nm, respectively. PANI-Au and PANI-Au-Pt nanocomposites were also spherical in shape with particle sizes at 3 and 2nm, respectively. Pristine PANI, PANI-Au, and PANI-Au-Pt nanocomposites were subjected to antibacterial activity against gram-positive (Bacillus subtilis and Staphylococcus aureus) and gram-negative (Escherichia coli and Vibrio cholerae) bacterial pathogens. PANI-Au-Pt nanocomposite showed significant antibacterial activity (33 +/- 1.10mm dia) against B. subtilis. Besides, the MIC of pristine PANI, PANI-Au, and PANI-Au-Pt nanocomposites were found to be 75, 50 and 25 mu g/mL, respectively. Besides, the in vitro anticancer investigations against HepG2 liver cancer cells revealed the highest cytotoxicity for PANI-Au-Pt nanocomposite (21.25 mu g/mL) followed by PANI-Au nanocomposite (32 mu g/mL) and pristine PANI (49 mu g/mL). Overall, the present study showed considerable antibacterial and anticancer activity and suggested their potential use in pharmaceuticals after completing successful clinical trials for safety and affordability.
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