期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1598, 期 -, 页码 39-48出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2019.03.053
关键词
Farrerol; Magnetic extraction and purification; Graphene oxide; Surface molecular imprinting
资金
- Key Projects of the National Science and Technological Pillar Program [2015BAD1101]
- earmarked fund for the China Agriculture Research System [CAR-38]
- Special Fund for Agro-scientific Research in Tibet Autonomous Region of China [XZNKY-2018-C-029]
- National Natural Science Foundation of China [31471654, 31772071, 31501571]
- China Agriculture Research System [CARS-05-05A-03]
Herein, a novel magnetic molecularly imprinted polymer doped with reticular graphene oxide (Fe3O4@SiO2-GO@MIPs) was synthesized for the selective recognition and extraction of 4 flavonoids (farrerol, taxifolin, kaempferol, and hyperin) from Rhododendrons species. The Fe3O4@SiO2-GO@MIPs with lamellar membranes showed outstanding adsorption capacity. The 3D cavities complementary to the shape of farrerol were imprinted on the polymer framework after removal of farrerol template. Competitive binding assays showed that the polymer has a higher selectivity for farrerol compared with other analogues and references. The Fe3O4@SiO2-GO@MIPs as solid-phase extraction adsorbents combined with liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS) was used for selective determination of four flavonoids from Rhododendrons samples. The limits of detection (LOD) were 0.07, 0.08, 0.06, and 0.08 mu g L-1 for farrerol, taxifolin, kaempferol, and hyperin, respectively. These results suggest that the prepared Fe3O4@SiO2-GO@MIPs have the potential applicability to extract, purify, and enrich flavonoids from herbs, supplements, and other natural products. (C) 2019 Elsevier B.V. All rights reserved.
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