期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 95, 期 5, 页码 1090-1093出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.16-0483
关键词
-
资金
- German Federal Ministry of Education and Research [01DG13006A]
- German Federal Ministry for Economic Cooperation and Development via the ESTHER program
- German Research Foundation (DFG) [GRK2046]
- DFG grant [GRK1673]
- Sonnenfeld-Foundation, Berlin
Emerging artemisinin resistance is a threat to global malaria control. Mutations in the Plasmodium falciparum Kelch 13 (K13) propeller domain confer artemisinin resistance and constitute molecular markers for its detection and monitoring. We sequenced 222 P. falciparum isolates obtained from community children in the Huye District of southern Rwanda in 2010, 2014, and 2015 to investigate the presence of K13 polymorphisms. No polymorphisms were observed in 2010 but they were present in 2.5% and 4.5% in 2014 and 2015, respectively. In 2015, two isolates showed candidate K13 resistance mutations (P574L and A675V), which are common in southeast Asia and associated with delayed parasite clearance. K13 polymorphisms in southern Rwanda are infrequent but include variants associated with artemisinin resistance. Establishing correlations with local treatment response and in vitro resistance assays are needed in addition to further monitoring K13 polymorphisms in the study area.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据