期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 94, 期 6, 页码 1245-1250出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.15-0446
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资金
- SAMS
- Velux Foundation
Despite the recommendation for the use of merozoite surface protein 1 (mspl), merozoite surface protein 2 (msp2), and glutamate-rich protein (glurp) genes as markers in drug efficacy studies by World Health Organization and their limited use in Bangladesh, the circulating Plasmodium falciparum population genetic structure has not yet been assessed in Bangladesh. This study presents a comprehensive report on the circulating P. falciparum population structure based on mspl, msp2, and glurp polymorphic gene markers in Bangladesh. Among the 130 pretreatment (day 0) P. falciparum samples from seven malaria-endemic districts, 14 distinct genotypes were observed for mspl, 20 for msp2, and 13 for glurp. Polyclonal infection was reported in 94.6% (N = 123) of the samples. Multiplicity of infection (MOI) for mspl was the highest (1.5) among the MOIs of the markers. The heterozygosity for mspl, msp2, and glurp was 0.89, 0.93, and 0.83, respectively. Data according to different malaria-endemic areas are also presented and discussed. Bangladesh is considered as a malaria-hypoendemic country. However, the prevalence of polyclonal infection and the genetic diversity of P falciparum do not represent hypoendemicity.
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