期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 10, 页码 17100-17112出版社
WILEY
DOI: 10.1002/jcp.28464
关键词
cancer; lncRNA; taurine-upregulated gene 1; TUG1
资金
- Shahid Beheshti University of Medical Sciences
Taurine-upregulated gene 1 (TUG1) is a 7.1kb long noncoding RNA (lncRNA) first recognized in 2005 as an important element for retinal development in rodents. Subsequently, this lncRNA has been shown to participate in oncogenic processes through alteration in chromatin structure, sponging microRNAs, and affecting the expression of some cancer-related pathways. While most of the studies have revealed an oncogenic role for this lncRNA, some reports have shown downregulation of TUG1 in lung cancer samples compared with noncancerous samples. In triple negative breast cancer samples, the expression of this lncRNA has been decreased. Besides, its expression has been higher in HER2-enriched and basal-like subtypes compared with luminal A. In the current review, we discuss the latest literature about the expression pattern and functional roles of TUG1 in diverse cancer types. In addition, its role in epithelial-mesenchymal transition and activation of Wnt/beta-catenin pathway in human malignancies will be explored.
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