期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 9, 页码 14838-14851出版社
WILEY
DOI: 10.1002/jcp.28303
关键词
bone remodeling; extracellular vesicles; microRNAs; tooth development
资金
- Sichuan University
- Shenzhen basic research grant [JCYJ20170307100446585]
- National Natural Science Foundation of China [81801032, 31670951, 31370992, 81874027]
- Science and Technology Project of Sichuan Province [2018SZ0269, 2018SZ0202, 2014SZ0019]
Bone and tooth, fundamental parts of the craniofacial skeleton, are anatomically and developmentally interconnected structures. Notably, pathological processes in these tissues underwent together and progressed in multilevels. Extracellular vesicles (EVs) are cell-released small organelles and transfer proteins and genetic information into cells and tissues. Although EVs have been identified in bone and tooth, particularly EVs have been identified in the bone formation and resorption, the concrete roles of EVs in bone and tooth development and diseases remain elusive. As such, we review the recent progress of EVs in bone and tooth to highlight the novel findings of EVs in cellular communication, tissue homeostasis, and interventions. This will enhance our comprehension on the skeletal biology and shed new light on the modulation of skeletal disorders and the potential of genetic treatment.
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