期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 10, 页码 17295-17304出版社
WILEY
DOI: 10.1002/jcp.28347
关键词
apoptosis; curcumin; diabetic retinopathy (DR); heme oxygenase-1 (HO-1); retinal pigment epithelial (RPE) cells
资金
- Piano Triennale Ricerca
To study the effects of curcumin on human retinal pigment epithelial(RPE) cells exposed to high glucose (HG) insult, we performed in vitro studies on RPE cells cultured both in normal and HG conditions to assess the effects of curcumin on the cell viability, nuclear factor erythroid 2-related factor 2 (Nrf2) expression, HO-1 activity, and ERK1/2 expression. RPE cells exposed to HG insult were treated with curcumin. The cell viability, apoptosis, HO-1 activity, ERK, and Nrf2 expression were evaluated. The data indicated that treatment with curcumin caused a significant decrease in terms of apoptosis. Further, curcumin was able to induce HO-1 expression via Nrf2 activation and counteracts the damage elicited by HG. The present study demonstrated that curcumin provides protection against HG-induced damage in RPE cells through the activation of Nrf2/HO-1 signaling that involves the ERK pathway, suggesting that curcumin may have therapeutic value in the treatment of diabetic retinopathy.
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