期刊
JOURNAL OF CELL SCIENCE
卷 132, 期 6, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.226506
关键词
Microtubule acetylation; Arp2/3-branched actin; HDAC6; Cortactin; Mitochondria
类别
资金
- National Key R&D Program of China [2017YFA0506500]
- Natural Science Foundation of China [81672457, 81570421]
Actin and microtubule cytoskeletons regulate cell morphology, participate in organelle trafficking and function in response to diverse environmental cues. Precise spatial-temporal coordination between these two cytoskeletons is essential for cells to live and move. Here, we report a novel crosstalk between actin and microtubules, in which the branched actin maintains microtubule organization, dynamics and stability by affecting tubulin acetylation levels. We observed that acetylated tubulin significantly decreases upon perturbation of the Arp2/3-branched actin. We subsequently discover that HDAC6 participates in this process by altering its interaction with tubulin and the Arp2/3-stabilizer cortactin. We further identify that the homeostasis of branched actin controls mitochondrial distribution via this microtubule acetylation-dependent mechanism. Our findings shed new light on the integral view of cytoskeletal networks, highlighting post-translational modification as another possible form of cytoskeletal inter-regulation, aside from the established crosstalks through structural connection or upstream signaling pathways.
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