期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 145, 期 4, 页码 927-939出版社
SPRINGER
DOI: 10.1007/s00432-018-02838-3
关键词
Mistletoe; Cancer; Complementary and alternative medicine (CAM); Patient-relevant outcomes
类别
资金
- German Guideline S3 Leitlinie Komplementarmedizin in der Behandlung von onkologischen PatientInnen [032-055OL]
- German Cancer Aid within the German Guideline Program in Oncology [11583]
- working group Prevention and Integrative Oncology of the German Cancer Society
PurposeOne important goal of any cancer therapy is to improve or maintain quality of life. In this context, mistletoe treatment is discussed to be highly controversial. The aim of this systematic review is to give an extensive overview about the current state of evidence concerning mistletoe therapy of oncologic patients regarding quality of life and side effects of cancer treatments.MethodsIn September and October 2017, Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, CINAHL and Science Citation Index Expanded (Web of Science) were systematically searched.ResultsThe search strategy identified 3647 articles and 28 publications with 2639 patients were finally included in this review. Mistletoe was used in bladder cancer, breast cancer, other gynecological cancers (cervical cancer, corpus uteri cancer, and ovarian cancer), colorectal cancer, other gastrointestinal cancer (gastric cancer and pancreatic cancer), glioma, head and neck cancer, lung cancer, melanoma and osteosarcoma. In nearly all studies, mistletoe was added to a conventional therapy. Regarding quality of life, 17 publications reported results. Studies with better methodological quality show less or no effects on quality of life.ConclusionsWith respect to quality of life or reduction of treatment-associated side effects, a thorough review of the literature does not provide any indication to prescribe mistletoe to patients with cancer.
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