期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 16, 期 9, 页码 2704-2713出版社
WILEY
DOI: 10.1111/ajt.13807
关键词
clinical research; practice; translational research; science; endocrinology; diabetology; islet transplantation; diabetes: type 1; immunosuppressant; immunosuppressive regimens; islets of Langerhans
资金
- Juvenile Diabetes Foundation International
- Alberta Innovates Health Solutions
- National Institutes for Health
- Alberta Innovates [201201154] Funding Source: researchfish
- National Institute for Health Research [CL-2015-23-001] Funding Source: researchfish
The beta score, a composite measure of beta cell function after islet transplantation, has limited sensitivity because of its categorical nature and requires a mixed-meal tolerance test (MMTT). We developed a novel score based on a single fasting blood sample. The BETA-2 score used stepwise forward linear regression incorporating glucose (in millimoles per liter), C-peptide (in nanomoles per liter), hemoglobin A1c (as a percentage) and insulin dose (U/kg per day) as continuous variables from the original beta score data set (n=183 MMTTs). Primary and secondary analyses assessed the score's ability to detect glucose intolerance (90-min MMTT glucose 8mmol/L) and insulin independence, respectively. A validation cohort of islet transplant recipients (n=114 MMTTs) examined 12mo after transplantation was used to compare the score's ability to detect these outcomes. The BETA-2 score was expressed as follows (range 0-42): A score <20 and 15 detected glucose intolerance and insulin independence, respectively, with >82% sensitivity and specificity. The BETA-2 score demonstrated greater discrimination than the beta score for these outcomes (p<0.05). Using a fasting blood sample, the BETA-2 score estimates graft function as a continuous variable and shows greater discrimination of glucose intolerance and insulin independence after transplantation versus the beta score, allowing frequent assessments of graft function. Studies examining its utility to track long-term graft function are required. Using regression analyses from the original Edmonton islet transplant recipients' fasting C-peptide, fasting glucose, HbA1c and insulin requirements, the authors derive a new score of islet engraftment from a single fasting blood sample, then validate it in a separate cohort of islet transplant recipients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据