期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 144, 期 2, 页码 536-548出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2018.11.051
关键词
Allergy; allergen; allergen-specific IgG; birth cohort; breast milk; cord blood; maternal IgG; microarrayed allergens; recombinant allergen; sensitization
资金
- Austrian Science Fund (FWF) [F4605, P25921-B21]
- Swedish Medical Research Council
- Centre for Allergy Research Karolinska Institutet
- Stockholm County Council
- Karolinska Institutet
- Karolinska University Hospital, Phadia AB
- Swedish Asthma and Allergy Research Association
- Swedish Research Council for Working Life and Social Research
- Cancer and Allergy Fund
- Mjolkdroppen'' Society
- Ekhaga Foundation
- Frimurare Barnhuset'' in Stockholm Foundation
- Hesselman Foundation, Sweden
- Megagrant of the Government of the Russian Federation [14.W03.31.0024]
- Austrian Science Fund (FWF) [P25921] Funding Source: Austrian Science Fund (FWF)
Background: Analysis of allergen-specific IgE responses in birth cohorts with microarrayed allergens has provided detailed information regarding the evolution of specific IgE responses in children. High-resolution data regarding early development of allergen-specific IgG are needed. Objective: We sought to analyze IgG reactivity to microarrayed allergens in mothers during pregnancy, in cord blood samples, in breast milk, and in infants in the first years of life with the aim to investigate whether maternal allergen-specific IgG can protect against IgE sensitization in the offspring. Methods: Plasma samples from mothers during the third trimester, cord blood, breast milk collected 2 months after delivery, and plasma samples from children at 6, 12, and 60 months of age were analyzed for IgG reactivity to 164 microarrayed allergens (ImmunoCAP ISAC technology) in 99 families of the Swedish birth cohort Assessment of Lifestyle and Allergic Disease During Infancy (ALADDIN). IgE sensitizations to microarrayed allergens were determined at 5 years of age in the children. Results: Allergen-specific IgG reactivity profiles in mothers, cord blood, and breast milk were highly correlated. Maternal allergen-specific IgG persisted in some children at 6 months. Children's allergen-specific IgG production occurred at 6 months and reflected allergen exposure. Children who were IgE sensitized against an allergen at 5 years of age had significantly higher allergen-specific IgG levels than nonsensitized children. For all 164 tested allergens, children from mothers with increased (>30 ISAC standardized units) specific plasma IgG levels against an allergen had no IgE sensitizations against that allergen at 5 years of age. Conclusion: This is the first detailed analysis of the molecular IgG recognition profile in mothers and their children in early life. High allergen-specific IgG reactivity in the mother's plasma and breast milk and in cord blood seemed to protect against allergic sensitization at 5 years of age.
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