期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 11, 页码 3140-3149出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b06402
关键词
Lycium ruthenicum Murr; anthocyanins; oxidative stress; memory impairment; neuroinflammation; neurodegeneration
资金
- National Natural Science Foundation of China [31800297]
- Qinghai Provincial Science Foundation [2017-SF-A8]
- Innovation Platform for the Development and Construction of Special Project of Key Laboratory of Tibetan Medicine Research of Qinghai Province [2017-ZJ-Y11]
- Qinghai Province International Cooperation Project [2018-HZ-812]
Lycium ruthenicum Murr. (LR) is a perennial shrub commonly used as a nutritional food and medicine. Herein, we identified 12 anthocyanins from LR, with petunidin derivatives constituting approximately 97% of the total anthocyanin content. Furthermore, the potential mechanism of anthocyanins exerting neuroprotective effects in D-galactose (D-gal)-treated rats was explored. Behavioral results showed that anthocyanins relieved D-gal-induced memory disorder. Additionally, anthocyanins reduced receptor for advanced glycation end products (RAGE) and suppressed oxidative stress caused by D-gal. Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappa B), interleukin-1-beta (IL-1 beta)cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Moreover, anthocyanins lowered C-jun N-terminal kinase (p-JNK), caspase-3 levels, and the B-cell lymphoma 2-associated X protein/B-cell lymphoma 2 (Bax/Bcl2) ratio. Thus, anthocyanins from LR attenuated memory disfunction, neuroinflammation, and neurodegeneration caused by D-gal, possibly through the RAGE/NF-kappa B/JNK pathway, representing a promising, safe candidate for prevention and therapy of neurodegenerative diseases.
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