期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 245, 期 -, 页码 1089-1097出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jad.2018.11.095
关键词
Magnetic resonance imaging; Diffusion tensor imaging; Suicide; Adolescent; Young Adult; Frontal Lobe
资金
- NIH [RC1 MH088366, R01 MH69747, R01 MH070902]
- National Center for Advancing Translational Science [UL1TR000142, T32 MH014276, T32DA022975]
- American Foundation for Suicide Prevention
- International Bipolar Disorder Foundation
- Brain and Behavior Research Foundation
- MQ Brighter Futures Program
- For the Love of Travis Foundation
- Women's Health Research at Yale
- AIM Foundation
- John and Hope Furth Endowment
Background: Findings regarding brain circuitry abnormalities in suicide attempters (SAs) converge across bipolar disorder (BD) and major depressive disorder (MDD), the most common disorders observed in suicides. These abnormalities appear to be present during adolescence/young adulthood when suicide rates increase steeply, and suicide is a leading cause of death in this age group. Identification of brain circuitry common to adolescent/young adult SAs with BD and MDD is important for generating widely effective early prevention strategies. We examined brain circuitry in SAs in adolescents/young adults across these two disorders. Methods: Eighty-three participants (ages 14-25 years), 46 with BD (21 SAs) and 37 with MDD (19 SAs), underwent structural and diffusion-weighted magnetic resonance scanning. Whole-brain analyses compared gray matter (GM) volume and white matter (WM) fractional anisotropy (FA) between SAs and non-suicide attempters (NSAs) across and within BD and MDD (p < 0.005). Results: Across and within BD and MDD, SAs showed differences compared to NSAs in ventral prefrontal cortex (PFC) GM volume and fronto-limbic (including uncinate fasciculus (UF)) WM FA. Exploratory analyses showed additional within-disorder differences for BD SAs in dorsolateral PFC (dlPFC) and hippocampus GM volume and UF FA, and for MDD SAs dorsomedial and dlPFC GM and dorsal frontal WM. However, there was no significant interaction between suicide attempt status and diagnosis. Limitations: Modest sample size. Conclusions: Common fronto-limbic gray and white matter alterations in adolescent/young adult SAs are potential targets for suicide prevention strategies across mood disorders. Preliminary findings of disorder-specific regional findings could suggest diagnostic-specific optimal targets may exist.
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