期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 559, 期 -, 页码 255-270出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2019.01.044
关键词
Mucogel; Electro-responsive; Thermosensitive; Nanocomposite; Mucoadhesive; Nose-to-brain delivery
资金
- National Research Foundation (NRF) of South Africa
The purpose of this work was to develop an in situ thermosensitive electro-responsive mucoadhesive gel loaded with bioactive agent (nanocomposite) meant for nose to brain delivery in a controllable manner when electric stimulation is applied. Nanocomposite was developed using a combinatorial blending of chitosan, hydro-xypropylmethylcellulose, pluronic F127 and polyaniline which was then loaded with BCNU-Nano-co-Plex (the bioactive agent). The nanocomposite was a liquid at room temperature but formed an in situ mucogel at a temperature of 27.5 +/- 0.5 degrees C. Furthermore, the nanocomposite possessed a redox element which makes it responsive to electrical stimulation (ES). The stimuli responsiveness enabled the formulation to release the bioactive agent when electrical potential was applied and demonstrated a desired 10.28% release of nanoparticles per application cycle. The results further revealed pore formation within the formulation which accommodated the loaded nanoparticles. The release profile also demonstrated a pulsatile release of the bioactive material when subjected to ES. This formulation may therefore be useful as a nose to brain drug delivery system that can be modulated to deliver bioactive agents to the brain via electro-actuation in an on-off drug release kinetics by means of an external ES for a controlled nose-to-brain delivery.
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