期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 14, 期 -, 页码 1519-1532出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S184192
关键词
gold nanorices; dual-mesoporous silica; confined growth; imaging; photothermal effect
资金
- National Natural Science Foundation of China for Innovative Research Groups [51621002]
- National Key Research and Development Program of China [2016YFA0203700]
- NSFC [51572083, 51572084, 51461165202, 51472085]
- Basic Research Program of Shanghai [17JC1404702]
- Shanghai Rising-Star Program [16QA1401300]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- 111 project [B14018]
- Fundamental Research Funds for Central Universities [222201718002]
Introduction: In this work, we have developed a novel confined-growth strategy to synthesize PEGylated multiple gold nanorices-encapsulated dual-mesoporous silica nanospheres (designated as PEGylated MGNRs@DMSSs) containing both small mesopores (2.5 nm) in the shell and large mesopores (21.7 nm) in the core based on a well-established, seed-mediated growth method. The photothermal effect and CT imaging ability were also studied. Methods: The nanoparticles were characterized by Fourier transform infrared (FT-IR) spectra, N-2 absorption isotherms, Field-emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), Inductively coupled plasma atomic emission spectroscopy (ICP-AES) and Confocal microscopy. Results: The longitudinally-localized surface (LSPR) absorption properties of MGNRs@DMSSs can be easily tuned by altering the amount of HAuCl4 in the gold growth solution. Additionally, the resultant PEGylated MGNRs@DMSSs have monodispersed, spherical morphology and good colloidal stability in an aqueous solution. More importantly, when exposed to NIR irradiation, the PEGylated MGNRs@DMSSs exhibit both higher temperature increments and better photothermal effects than that of single PEGylated gold nanorods at nearly an equivalent LSPR absorption. In addition, as CT contrast agents, the PEGylated MGNRs@DMSSs display a better CT imaging performance, in comparison with single PEGylated gold nanorods at the same Au concentration. Conclusion: Taken together, results indicate the potential for MGNRs@DMSSs used in CT imaging-guided photothermal therapy. Such a simple confined-growth strategy within a porous matrix offers a promising platform to design and prepare novel metal(s) oxide@silica nanocomposites for use in further cancer bio-imaging and therapy.
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