期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms20051048
关键词
Zika virus; autophagy; Akt-mTOR; innate immunity; therapeutic targets
资金
- National Council for the Improvement of Higher Education, Brazil (CAPES) [001]
- National Council for Scientific and Technological Development, Brazil (CNPq)
- Department of Science and Technology of the Ministry of Health, Brazil (Decit/SCTIE/MS)
- IRCCS Burlo Garofolo grant Ricerca Corrente [RC09/17]
Zika virus (ZIKV) still constitutes a public health concern, however, no vaccines or therapies are currently approved for treatment. A fundamental process involved in ZIKV infection is autophagy, a cellular catabolic pathway delivering cytoplasmic cargo to the lysosome for degradationconsidered as a primordial form of innate immunity against invading microorganisms. ZIKV is thought to inhibit the Akt-mTOR signaling pathway, which causes aberrant activation of autophagy promoting viral replication and propagation. It is therefore appealing to study the role of autophagic molecular effectors during viral infection to identify potential targets for anti-ZIKV therapeutic intervention.
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