Postoperative prognostic nutritional index change is an independent predictor of survival in patients with small hepatocellular carcinoma

BACKGROUND: There is limited information concerning the postoperative prognostic nutritional index change (Delta PNI) in hepatocellular carcinoma (HCC). This study was designed to evaluate the prognostic value of DPNI in patients with small HCC who underwent liver resection. METHODS: A retrospective cohort study was performed to analyze 243 patients with small HCC who underwent liver resection. Patients were divided into prognostic nutritional index (PNI)-increased group (n = 161) and PNI-decreased group (n = 82) according to postoperative PNI change. Clinical data, overall survival (OS), and recurrence-free survival (RFS) were statistically compared between the 2 groups, and a multivariate analysis was used to identify prognostic factors. RESULTS: Multivariable analysis revealed that Delta PNI as independent predictors of OS and RFS in patients with small HCC after liver resection (P < .01 for both). CONCLUSIONS: Decreased PNI, but not low preoperative PNI was an independent risk factor for OS and RFS in patients with small HCC who underwent liver resection. (C) 2015 Elsevier Inc. All rights reserved.