4.7 Review

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

Rosa Puertollano et al.

EMBO JOURNAL (2018)

Review Biotechnology & Applied Microbiology

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

Barry Boland et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Multidisciplinary Sciences

mTOR-dependent phosphorylation controls TFEB nuclear export

Gennaro Napolitano et al.

NATURE COMMUNICATIONS (2018)

Review Neurosciences

Therapeutic potential of autophagy-enhancing agents in Parkinson's disease

Tim E. Moors et al.

MOLECULAR NEURODEGENERATION (2017)

Review Biochemistry & Molecular Biology

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

Yvette C. Wong et al.

NATURE MEDICINE (2017)

Article Neurosciences

The two-century journey of Parkinson disease research

Serge Przedborski

NATURE REVIEWS NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells

Bogdan Beirowski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

Chiara Di Malta et al.

SCIENCE (2017)

Review Oncology

Targeting autophagy in cancer

Jean M. Mulcahy Levy et al.

NATURE REVIEWS CANCER (2017)

Review Cell Biology

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

Nina Raben et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32 (2016)

Review Biochemistry & Molecular Biology

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

Jonathan M. Backer

BIOCHEMICAL JOURNAL (2016)

Review Cell Biology

Structure and function of the ULK1 complex in autophagy

Mary G. Lin et al.

CURRENT OPINION IN CELL BIOLOGY (2016)

Review Cell Biology

Lysosomal signaling in control of degradation pathways

Lukas A. Huber et al.

CURRENT OPINION IN CELL BIOLOGY (2016)

Article Medicine, Research & Experimental

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

Verena Albert et al.

EMBO MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy

Jiqian Zhang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

Cindy Puente et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Multidisciplinary Sciences

PtdIns(4,5) P2 signaling regulates ATG14 and autophagy

Xiaojun Tan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Nutrition & Dietetics

The Roles of mTOR Complexes in Lipid Metabolism

Alexandre Caron et al.

ANNUAL REVIEW OF NUTRITION, VOL 35 (2015)

Editorial Material Biochemistry & Molecular Biology

Scissors for autolysosome tubules

Yang Chen et al.

EMBO JOURNAL (2015)

Article Biochemistry & Molecular Biology

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

Michael J. Munson et al.

EMBO JOURNAL (2015)

Review Oncology

The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

Seiji Mabuchi et al.

GYNECOLOGIC ONCOLOGY (2015)

Article Biochemistry & Molecular Biology

Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling

Shanshan Gao et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Significance of filamin A in mTORC2 function in glioblastoma

Naphat Chantaravisoot et al.

MOLECULAR CANCER (2015)

Article Biochemistry & Molecular Biology

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Daniel F. Egan et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease

Nikhil M. Urs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Cell Biology

Regulation of mTORC1 by PI3K signaling

Christian C. Dibble et al.

TRENDS IN CELL BIOLOGY (2015)

Review Cell Biology

The Functions of MicroRNAs: mRNA Decay and Translational Repression

Hiro-oki Iwakawa et al.

TRENDS IN CELL BIOLOGY (2015)

Review Genetics & Heredity

Progress in unraveling the genetic etiology of Parkinson disease in a genomic era

Aline Verstraeten et al.

TRENDS IN GENETICS (2015)

Review Pharmacology & Pharmacy

Current treatment strategies for inhibiting mTOR in cancer

Francesca Chiarini et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2015)

Article Oncology

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Pengda Liu et al.

CANCER DISCOVERY (2015)

Review Biochemistry & Molecular Biology

The complexity of miRNA-mediated repression

A. Wilczynska et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Clinical Neurology

Progressive decline of glucocerebrosidase in aging and Parkinson's disease

Emily M. Rocha et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)

Article Neurosciences

miR-7 and miR-153 protect neurons against MPP+-induced cell death via upregulation of mTOR pathway

Apostolia Fragkouli et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Cell Biology

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

Sean J. Humphrey et al.

CELL METABOLISM (2013)

Article Cell Biology

Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity

Yasuhiro Araki et al.

JOURNAL OF CELL BIOLOGY (2013)

Review Medicine, Research & Experimental

Rapalogs and mTOR inhibitors as anti-aging therapeutics

Dudley W. Lamming et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

Mickael Decressac et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Chemistry, Medicinal

Advances with microRNAs in Parkinson's disease research

Liuqing Ma et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2013)

Review Pharmacology & Pharmacy

The Pharmacology of L-DOPA-Induced Dyskinesia in Parkinson's Disease

Philippe Huot et al.

PHARMACOLOGICAL REVIEWS (2013)

Article Medicine, Research & Experimental

Neurotoxin-Induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling

Senthil Selvaraj et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Neurosciences

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia

Srinivasa Subramaniam et al.

NATURE NEUROSCIENCE (2012)

Article Clinical Neurology

Dopaminergic Pathway Reconstruction by Akt/Rheb-Induced Axon Regeneration

Sang Ryong Kim et al.

ANNALS OF NEUROLOGY (2011)

Article Cell Biology

Chaperone-mediated autophagy in protein quality control

Esperanza Arias et al.

CURRENT OPINION IN CELL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models

Andrii Domanskyi et al.

FASEB JOURNAL (2011)

Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

Review Neurosciences

Fighting neurodegeneration with rapamycin: mechanistic insights

Jordi Bove et al.

NATURE REVIEWS NEUROSCIENCE (2011)

Article Multidisciplinary Sciences

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

Libin Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

Kohichi Matsunaga et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Neurosciences

Rapamycin Protects against Neuron Death in In Vitro and In Vivo Models of Parkinson's Disease

Cristina Malagelada et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Neurosciences

Pathogenic Lysosomal Depletion in Parkinson's Disease

Benjamin Dehay et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

Termination of autophagy and reformation of lysosomes regulated by mTOR

Li Yu et al.

NATURE (2010)

Review Neurosciences

mTOR signaling: At the crossroads of plasticity, memory and disease

Charles A. Hoeffer et al.

TRENDS IN NEUROSCIENCES (2010)

Article Cell Biology

Atg101, a novel mammalian autophagy protein interacting with Atg13

Nao Hosokawa et al.

AUTOPHAGY (2009)

Article Cell Biology

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Chang Hwa Jung et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Multidisciplinary Sciences

A Gene Network Regulating Lysosomal Biogenesis and Function

Marco Sardiello et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

Emanuela Santini et al.

SCIENCE SIGNALING (2009)

Article Biochemistry & Molecular Biology

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Laura R. Pearce et al.

BIOCHEMICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Yasemin Sancak et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein

Sovan Sarkar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Behavioral Sciences

mTOR signaling in the hippocampus is necessary for memory formation

Pedro Bekinschtein et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2007)

Article Biochemistry & Molecular Biology

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

Maria A. Frias et al.

CURRENT BIOLOGY (2006)

Review Biochemistry & Molecular Biology

TOR signaling in growth and metabolism

S Wullschleger et al.

Review Biochemistry & Molecular Biology

TOR signaling in growth and metabolism

Stephan Wullschleger et al.

Article Multidisciplinary Sciences

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 30H-kinase

T Nobukuni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Cell Biology

Lithium induces autophagy by inhibiting inositol monophosphatase

S Sarkar et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

MP Byfield et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Rheb binds and regulates the mTOR kinase

X Long et al.

CURRENT BIOLOGY (2005)

Article Biochemistry & Molecular Biology

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

MN Corradetti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

DD Sarbassov et al.

SCIENCE (2005)

Review Cell Biology

The Rheb family of GTP-binding proteins

PJ Aspuria et al.

CELLULAR SIGNALLING (2004)

Review Neurosciences

Parkinson's disease: Mechanisms and models

W Dauer et al.

NEURON (2003)

Article Cell Biology

Akt regulates growth by directly phosphorylating Tsc2

CJ Potter et al.

NATURE CELL BIOLOGY (2002)

Article Cell Biology

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

K Inoki et al.

NATURE CELL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

K Hara et al.