相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。MTOR Pathway-Based Discovery of Genetic Susceptibility to L-DOPA-Induced Dyskinesia in Parkinson's Disease Patients
Nuria Martin-Flores et al.
MOLECULAR NEUROBIOLOGY (2019)
Lung function response and side effects to rapamycin for lymphangioleiomyomatosis: a prospective national cohort study
Janet Bee et al.
THORAX (2018)
Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models
Jia Liu et al.
AUTOPHAGY (2018)
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization
Rosa Puertollano et al.
EMBO JOURNAL (2018)
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Barry Boland et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
mTOR-dependent phosphorylation controls TFEB nuclear export
Gennaro Napolitano et al.
NATURE COMMUNICATIONS (2018)
Therapeutic potential of autophagy-enhancing agents in Parkinson's disease
Tim E. Moors et al.
MOLECULAR NEURODEGENERATION (2017)
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
Bin Wang et al.
NATURE (2017)
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
Yvette C. Wong et al.
NATURE MEDICINE (2017)
The two-century journey of Parkinson disease research
Serge Przedborski
NATURE REVIEWS NEUROSCIENCE (2017)
mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells
Bogdan Beirowski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth
Chiara Di Malta et al.
SCIENCE (2017)
NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models
Chuanbin Yang et al.
AUTOPHAGY (2017)
MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy
Xi Ma et al.
AUTOPHAGY (2017)
Targeting autophagy in cancer
Jean M. Mulcahy Levy et al.
NATURE REVIEWS CANCER (2017)
TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress
Nina Raben et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32 (2016)
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition
Ju-Xian Song et al.
AUTOPHAGY (2016)
Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex
Yohei Ohashi et al.
AUTOPHAGY (2016)
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
Jonathan M. Backer
BIOCHEMICAL JOURNAL (2016)
Structure and function of the ULK1 complex in autophagy
Mary G. Lin et al.
CURRENT OPINION IN CELL BIOLOGY (2016)
Lysosomal signaling in control of degradation pathways
Lukas A. Huber et al.
CURRENT OPINION IN CELL BIOLOGY (2016)
mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue
Verena Albert et al.
EMBO MOLECULAR MEDICINE (2016)
Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy
Jiqian Zhang et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)
Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy
Cindy Puente et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia
Alberto Brugnoli et al.
NEUROBIOLOGY OF DISEASE (2016)
PtdIns(4,5) P2 signaling regulates ATG14 and autophagy
Xiaojun Tan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model
Jia Liu et al.
ONCOTARGET (2016)
The Roles of mTOR Complexes in Lipid Metabolism
Alexandre Caron et al.
ANNUAL REVIEW OF NUTRITION, VOL 35 (2015)
Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease
Ziv Gan-Or et al.
AUTOPHAGY (2015)
Scissors for autolysosome tubules
Yang Chen et al.
EMBO JOURNAL (2015)
mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival
Michael J. Munson et al.
EMBO JOURNAL (2015)
The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer
Seiji Mabuchi et al.
GYNECOLOGIC ONCOLOGY (2015)
Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling
Shanshan Gao et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)
Significance of filamin A in mTORC2 function in glioblastoma
Naphat Chantaravisoot et al.
MOLECULAR CANCER (2015)
Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells
Bryan Wei Chen et al.
MOLECULAR CANCER THERAPEUTICS (2015)
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
Daniel F. Egan et al.
MOLECULAR CELL (2015)
Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease
Nikhil M. Urs et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Regulation of mTORC1 by PI3K signaling
Christian C. Dibble et al.
TRENDS IN CELL BIOLOGY (2015)
The Functions of MicroRNAs: mRNA Decay and Translational Repression
Hiro-oki Iwakawa et al.
TRENDS IN CELL BIOLOGY (2015)
Progress in unraveling the genetic etiology of Parkinson disease in a genomic era
Aline Verstraeten et al.
TRENDS IN GENETICS (2015)
Current treatment strategies for inhibiting mTOR in cancer
Francesca Chiarini et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
Pengda Liu et al.
CANCER DISCOVERY (2015)
A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
Guang Yang et al.
CELL REPORTS (2015)
The complexity of miRNA-mediated repression
A. Wilczynska et al.
CELL DEATH AND DIFFERENTIATION (2015)
Progressive decline of glucocerebrosidase in aging and Parkinson's disease
Emily M. Rocha et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)
mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity
Masaki Mizunuma et al.
AGING CELL (2014)
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
Ariadna Recasens et al.
ANNALS OF NEUROLOGY (2014)
HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression
Ju-Xian Song et al.
AUTOPHAGY (2014)
Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation
Benyu Ma et al.
CELL RESEARCH (2014)
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
Yijiao Xu et al.
CELLULAR SIGNALLING (2014)
Factors Predictive of the Development of Levodopa-Induced Dyskinesia and Wearing-Off in Parkinson's Disease
Ali H. Rajput
MOVEMENT DISORDERS (2014)
The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
Jose A. Martina et al.
SCIENCE SIGNALING (2014)
miR-7 and miR-153 protect neurons against MPP+-induced cell death via upregulation of mTOR pathway
Apostolia Fragkouli et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity
Jiahong Lu et al.
NATURE COMMUNICATIONS (2014)
Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy
Hai-Xin Yuan et al.
AUTOPHAGY (2013)
Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
Sean J. Humphrey et al.
CELL METABOLISM (2013)
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity
Yasuhiro Araki et al.
JOURNAL OF CELL BIOLOGY (2013)
Rapalogs and mTOR inhibitors as anti-aging therapeutics
Dudley W. Lamming et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson's Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy
Tian-Fang Jiang et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2013)
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
Mickael Decressac et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Advances with microRNAs in Parkinson's disease research
Liuqing Ma et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2013)
The Pharmacology of L-DOPA-Induced Dyskinesia in Parkinson's Disease
Philippe Huot et al.
PHARMACOLOGICAL REVIEWS (2013)
Neurotoxin-Induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling
Senthil Selvaraj et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia
Srinivasa Subramaniam et al.
NATURE NEUROSCIENCE (2012)
Dopaminergic Pathway Reconstruction by Akt/Rheb-Induced Axon Regeneration
Sang Ryong Kim et al.
ANNALS OF NEUROLOGY (2011)
Chaperone-mediated autophagy in protein quality control
Esperanza Arias et al.
CURRENT OPINION IN CELL BIOLOGY (2011)
Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
Andrii Domanskyi et al.
FASEB JOURNAL (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Fighting neurodegeneration with rapamycin: mechanistic insights
Jordi Bove et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
Libin Shang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
Kohichi Matsunaga et al.
JOURNAL OF CELL BIOLOGY (2010)
Rapamycin Protects against Neuron Death in In Vitro and In Vivo Models of Parkinson's Disease
Cristina Malagelada et al.
JOURNAL OF NEUROSCIENCE (2010)
Pathogenic Lysosomal Depletion in Parkinson's Disease
Benjamin Dehay et al.
JOURNAL OF NEUROSCIENCE (2010)
Termination of autophagy and reformation of lysosomes regulated by mTOR
Li Yu et al.
NATURE (2010)
Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
Leslie Crews et al.
PLOS ONE (2010)
mTOR signaling: At the crossroads of plasticity, memory and disease
Charles A. Hoeffer et al.
TRENDS IN NEUROSCIENCES (2010)
Atg101, a novel mammalian autophagy protein interacting with Atg13
Nao Hosokawa et al.
AUTOPHAGY (2009)
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson et al.
CELL (2009)
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
S. Sarkar et al.
CELL DEATH AND DIFFERENTIATION (2009)
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Chang Hwa Jung et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
A Gene Network Regulating Lysosomal Biogenesis and Function
Marco Sardiello et al.
SCIENCE (2009)
Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
Emanuela Santini et al.
SCIENCE SIGNALING (2009)
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
Laura R. Pearce et al.
BIOCHEMICAL JOURNAL (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein
Sovan Sarkar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
mTOR signaling in the hippocampus is necessary for memory formation
Pedro Bekinschtein et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2007)
RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation
Cristina Malagelada et al.
JOURNAL OF NEUROSCIENCE (2006)
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
Maria A. Frias et al.
CURRENT BIOLOGY (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 30H-kinase
T Nobukuni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Lithium induces autophagy by inhibiting inositol monophosphatase
S Sarkar et al.
JOURNAL OF CELL BIOLOGY (2005)
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
MP Byfield et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Rheb binds and regulates the mTOR kinase
X Long et al.
CURRENT BIOLOGY (2005)
The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway
MN Corradetti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
The Rheb family of GTP-binding proteins
PJ Aspuria et al.
CELLULAR SIGNALLING (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
J Brugarolas et al.
GENES & DEVELOPMENT (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
K Inoki et al.
GENES & DEVELOPMENT (2003)
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
DH Kim et al.
MOLECULAR CELL (2003)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
K Hara et al.
CELL (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)