期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ijms20030646
关键词
NK cells; immune signaling; biomaterials; nanodevices; artificial immune synapse
资金
- Israel Science Foundation [1401/15] Funding Source: Medline
- Israel Science Foundation - BIKURA [2058/18] Funding Source: Medline
Natural Killer (NK) cells are innate lymphocytes that contribute to immune protection by cytosis, cytokine secretion, and regulation of adaptive responses of T cells. NK cells distinguish between healthy and ill cells, and generate a cytotoxic response, being cumulatively regulated by environmental signals delivered through their diverse receptors. Recent advances in biomaterials and device engineering paved the way to numerous artificial microenvironments for cells, which produce synthetic signals identical or similar to those provided by the physiological environment. In this paper, we review recent advances in materials and devices for artificial signaling, which have been applied to regulate NK cells, and systematically study the role of these signals in NK cell function.
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