期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 124, 期 -, 页码 1060-1068出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2018.12.001
关键词
Glucuronorhamnoxylan; Colon cancer; Apoptosis
资金
- Gyeonggi-do GRRC Program of the Catholic University of Korea, South Korea [2017-B01]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, South Korea [2018R1A61A03023584]
- 2018 Research Fund of The Catholic University of Korea, South Korea
Colorectal cancer is the third most diagnosed cancer and a leading cause of cancer death. Dissatisfaction with currently available anti-colorectal cancer drugs caused by unwanted side effects and low efficacy necessitates new therapeutic agents. In the present study, a sulfated glucuronorhamnoxylan polysaccharide (named SPS-CF) purified from a green alga Capsosiphon fulvescens was evaluated for its anti-cancer activity in vitro and in vivo against colorectal cancer. The SPS-CF treatment resulted in a dose-dependent inhibition of the HT-29 human colon cancer cell growth up to 40% at 500 mu g/mL This inhibitory activity was shown to be mediated by upregulation of the cleavage of caspase-8,-9,-3 and poly (ADP-ribose) polymerase (PARP), induction of DNA fragmentation, and disruption of mitochondrial membrane potential (MMP), demonstrating that SPS-CF causes apoptotic death of HT-29 cancer cells though activation of caspase-dependant pathway. Administration of SPS-CF to BALB/c-nude mice bearing HT-29 cell-xenograft tumor also reduced the tumor growth. The results of this study demonstrated that the SPS-CF effectively inhibits the colorectal tumor growth both in vitro and in vivo by induction of apoptotic death of tumor cells, suggesting that it can be a potent ingredient for health-beneficial foods or anticancer agents to prevent or ameliorate human colon cancer. (C) 2018 Elsevier B.V. All rights reserved.
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