期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 123, 期 -, 页码 117-123出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.11.052
关键词
Antioxidant; Biomaterial; Copolymer; Esterification; Polyhydroxyalkanoates
资金
- Research Program to solve social issues of the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [2017M3A9E4077234]
- National Research Foundation of Korea (NRF) [NRF-2015M1A5A1037196, 2017R1D1A1B03030766]
- Polar Academic Program (PAP) [PE18900]
- National Research Foundation of Korea [2017R1D1A1B03030766] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Naturally produced polyhydroxyalkanoates (PHAs) biopolymers have limited medical applications due to their brittle and hydrophobic nature. In this study poly(3-hydroxybutyrate-co-3-hydroxyvalerate) P(3HB-co-3HV) co-polymer was produced using engineered Escherichia coli YJ101, and further functionalized with ascorbic acid using Candida antarctica lipase B mediated esterification. Copolymer P(3HB-co-3HV)-ascorbic acid showed lower degree of crystallinity (9.96%), higher thermal degradation temperature (294.97 degrees C) and hydrophilicity (68 degrees) as compared to P(3HB-co-3HV). Further, P(3HB-co-3HV)-ascorbic acid biomaterial showed 14% scavenging effect on 1,1-diphenyl-2-picryl-hydrazyl (DPPH), and 1.6 fold increase in biodegradability as compared to P(3HB-co-3HV). Improvement of PHAs polymer properties by adding functional groups could be a good approach to increase their biodegradability, economic value and important applications in the medical field. (C) 2018 Elsevier B.V. All rights reserved.
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