期刊
INTERNATIONAL HEART JOURNAL
卷 60, 期 2, 页码 280-286出版社
INT HEART JOURNAL ASSOC
DOI: 10.1536/ihj.18-306
关键词
Myocardial biomarker; Ischemic heart disease; Prognosis
资金
- National Natural Science Foundation of China [81600300]
- Natural Science Foundation of Zhejiang Province [LQ15H100001]
- Fundamental Research Funds for the Central Universities [2017QNA7016]
Patients with ischemic heart disease are associated with poor prognosis, and their number has increased globally. Therefore, biomarkers that could predict post-acute myocardial infarction (AMI) heart failure (HF) would be helpful to guide appropriate treatment. Based on the diagnosis on admission and results of echocardiogram performed on admission and 1 year after discharge, the current study recruited 54 patients with post-AMI HF, 59 patients with post-AMI non-HE and 59 healthy controls. Eight candidate microRNAs (miRs) were screened through real-time quantitative PCR. Serum circulating miR-150 level in the post-AMI HF group was significantly lower than the post-AMI non-HF group (0.4 +/- 0.3 versus 0.7 +/- 0.3, P < 0.001). Further analysis showed that serum circulating miR-150 level was associated with ejection fraction (EF) 1 year after discharge (P < 0.001). Receiver operating characteristic curve (ROC) analysis found that area under the ROC (AUC) was 0.616 (95%CI = 0.511-0.721, P = 0.034) when BNP was used to predict post-AMI HE whereas AUC improved to 0.764 (95%CI = 0.674-0.855, P < 0.001) when miR-150 was used. The combination of BNP and miR-150 significantly improved the AUC to 0.807 (95%CI = 0.727-0.886, P < 0.001). Finally. multivariate logistic regression analysis revealed that either LVEF on admission or serum circulating miR-150 level was independently associated with post-AMI HE Serum circulating miR-150 is a novel biomarker to predict post-AMI HE Further large sample prospective clinical research is needed to validate its role in the future.
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