Synthetic stratagem, characterization and biocidal applications of triorganotin(IV) complexes derived from hydrazide/hydrazone analogues

A series of Schiff base ligands as benzylidene benzohydrazide and their hydrazone analogues (I-a-I-c) have been synthesized and then complexed with organotin(IV) moiety having general formula [R'(3) SnL] to get the target compounds(1-9), where L = C4H3OCONHN=CHR, R = C6H5O(I-a), C4H5O(I-b), C6H3Cl2(I-c) and R' = -CH3(1-3), -CH2Ph(4-6), -Ph(7-9). They were fully characterized using FT-IR, NMR(H-1, C-13 and Sn-119) spectroscopy, along with elemental analysis and melting point. One of the precursor (I-b) has been analyzed by single crystal XRD to further authenticate the structure. The Sn-119 NMR data suggest the molecular geometry of organotin derivatives as distorted pentagonal bipyramidal. They were also evaluated for their antibacterial, antifungal, alpha-amylase inhibition, DPPH, total reducing power and total antioxidant activities. Triaryltin(IV) derivatives show good antibacterial and antifungal activity. Whereas the data for antidiabetic activity demonstrated that the compounds may serve as moderately effective alpha amylase inhibitor.