期刊
INFECTION GENETICS AND EVOLUTION
卷 68, 期 -, 页码 212-217出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2018.12.029
关键词
CSFV; Sub-subgenotype 2.1c; E2
资金
- National Key Research and Development Program of China
- Ministry of Science and Technology of the People's Republic of China [2017YFD0500101]
- National Natural Science Foundation of China [31572528]
- China Postdoctoral Science Foundation [2013M532129]
Classical swine fever (CSF) continues to be a devastating infectious disease for the swine industry in China and commonly exists as wild or atypical types. From June 3rd to October 3rd, 2018, outbreaks of typical CSF cases with mortality rates of 42-86% occurred in 11 swine herds in five cities of Guangdong province, and were confirmed by RT-PCR. Phylogenetic analyses based on the nucleotide sequences of full-length E2 genes showed that the CSFV isolates collected in Guangdong, 2018 grouped into sub-subgenotype 2.1c and formed a separate Glade from previously identified 2.1c isolates. Sequence comparison further confirmed the distance between the novel emergent and previously identified 2.1c isolates, with shared 94.5-98.2% and 97.8-99.7% identities at the nucleotide and amino acid levels respectively. Furthermore, 2.1c isolates collected in 2018 from Guangdong province contained a unique amino acid substitution (K174R) in the E2 protein in comparison with other 2.1c representative strains and CSFV 2.1, 2.2, 2.3 strains. Of note, the novel emergent 2.1c isolates are neutralized by sera from C-strain vaccinated sows, indicating that C-strain is still efficacious for protection against field isolates of CSFV.
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