期刊
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
卷 55, 期 4, 页码 302-311出版社
SPRINGER
DOI: 10.1007/s11626-019-00337-4
关键词
UC-MSCs; Collagen scaffold; POF; Ovarian function
资金
- National Nature Science Foundation of China [31571189, 81601277, 81871128, 81571391, 30900847]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01030501]
- Jiangsu Province Social Development Project [BE2018602]
- National Key Research and Development Program of China [2018YFC1004700]
- Nanjing Medical Science Development Project [JQX14004, ZKX16042]
- Jiangsu Provincial Medical Youth Talent [QNRC2016006]
Premature ovarian failure (POF) is a refractory disease; one of the most important goals of treatment is to improve fertility. In the study, collagen scaffold loaded with human umbilical cord-derived mesenchymal stem cells (collagen/UC-MSCs) transplantation in POF mice preserved ovarian function, as supported by increased estrogen (E-2) and anti-Mullerian hormone (AMH) levels, increased ovarian volume, and an increased number of antral follicles. Immunohistochemistry results of Ki67 indicated transplantation of collagen/UC-MSCs promoted granulosa cell proliferation, which is crucial to oocyte maturation and follicular development. Additionally, transplantation of collagen/UC-MSCs significantly promoted ovarian angiogenesis with the increased expression of CD31. In general, collagen/UC-MSCs transplantation probably is an effective therapeutic strategy of POF.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据