期刊
IMMUNOLOGICAL REVIEWS
卷 288, 期 1, 页码 149-160出版社
WILEY
DOI: 10.1111/imr.12736
关键词
humoral autoimmunity; intracellular pathogens; memory B cells; plasma cells; T-bet(+) B cells; tissue-resident memory B cells
类别
资金
- Congressionally Directed Medical Research Programs [W81XWH-14-1-0305]
- National Institute of Allergy and Infectious Diseases [AI118691, AI133998]
- National Heart, Lung, and Blood Institute [T32 HL07954]
B cells expressing the transcription factor T-bet have emerged as participants in a number of protective and pathogenic immune responses. T-bet(+) B cells characteristically differentiate in response to combined Toll-like receptor and cytokine signaling, contribute to protective immunity against intracellular pathogens via IgG2(a/c) production and antibody-independent mechanisms, and are prone to produce autoantibodies. Despite recent advances, a number of questions remain regarding the basic biology of T-bet(+) B cells and their functional niche within the immune system. Herein, we review the discovery and defining characteristics of the T-bet(+) B cell subset in both mice and humans. We further discuss their origins, the basis for their persistence, and their potential fate in vivo. Evidence indicates that T-bet(+) B cells represent a distinct, germinal center-derived memory population that may serve as an important therapeutic target for the improvement of humoral immunity and prevention of autoimmunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据