期刊
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
卷 54, 期 6, 页码 751-760出版社
AMER THORACIC SOC
DOI: 10.1165/rcmb.2015-0166PS
关键词
extracellular matrix; myofibroblasts; transforming growth factor-beta; pulmonary fibrosis; emphysema
资金
- National Institutes of Health (NIH) [P01 HL114470, R01 AG046210]
- NIH [HL102371]
- Veteren's Administration grant [I01BX001756]
Pulmonary fibrosis and emphysema are chronic lung diseases characterized by a progressive decline in lung function, resulting in significant morbidity and mortality. A hallmark of these diseases is recurrent or persistent alveolar epithelial injury, typically caused by common environmental exposures such as cigarette smoke. We propose that critical determinants of the outcome of the injury-repair processes that result in fibrosis versus emphysema are mesenchymal cell fate and associated extracellular matrix dynamics. In this review, we explore the concept that regulation of mesenchymal cells under the influence of soluble factors, in particular transforming growth factor-beta 1, and the extracellular matrix determine the divergent tissue remodeling responses seen in pulmonary fibrosis and emphysema.
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