期刊
HYPERTENSION IN PREGNANCY
卷 38, 期 2, 页码 65-72出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10641955.2019.1581215
关键词
Melatonin; preeclampsia; pathogenesis; pregnancy; meta-analysis
资金
- University Science Research Project of Jiangsu Province [16KJB330009]
- Chinese National Nature Science Foundation [81473008, 81673203, 81803271, 81573173, 81402626]
Objective: The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia. Methods: Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model. Results: The pooled SMD between case and control was 1.40 (95% CI: 0.26, 2.55; P = 0.02). And the pooled SMD between mild PE and severe PE was 5.25 (95% CI: 1.5, 9.01; P = 0.006). Conclusion: The meta-analysis illustrated that melatonin concentration was significantly lower in women with preeclampsia, and correlated with the severity of the disease.
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