期刊
HYPERTENSION
卷 73, 期 6, 页码 E87-E120出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HYP.0000000000000090
关键词
AHA Scientific Statements; blood pressure; hypertension; models; animal
资金
- NHLBI NIH HHS [R01 HL135089, P01 HL051971] Funding Source: Medline
- NIGMS NIH HHS [U54 GM115428, P20 GM121334] Funding Source: Medline
- NINDS NIH HHS [R01 NS095441, R37 NS089323] Funding Source: Medline
Hypertension is the most common chronic disease in the world, yet the precise cause of elevated blood pressure often cannot be determined. Animal models have been useful for unraveling the pathogenesis of hypertension and for testing novel therapeutic strategies. The utility of animal models for improving the understanding of the pathogenesis, prevention, and treatment of hypertension and its comorbidities depends on their validity for representing human forms of hypertension, including responses to therapy, and on the quality of studies in those models (such as reproducibility and experimental design). Important unmet needs in this field include the development of models that mimic the discrete hypertensive syndromes that now populate the clinic, resolution of ongoing controversies in the pathogenesis of hypertension, and the development of new avenues for preventing and treating hypertension and its complications. Animal models may indeed be useful for addressing these unmet needs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据