期刊
HYPERTENSION
卷 73, 期 2, 页码 335-341出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HYPERTENSIONAHA.118.12225
关键词
arterial pressure; atherosclerosis; blood pressure; epidemiology; pediatrics
资金
- US National Institutes of Health (NIH/National Heart, Lung and Blood Institute [NHLBI]) [R01 HL121230]
- Australian National Health and Medical Research Council [APP1098369, APP211316]
- National Heart Foundation of Australia Future Leader Fellowship [100849]
- Academy of Finland [126925, 121584, 124282, 129378, 117787, 41071]
- Social Insurance Institution of Finland
- Kuopio University Hospital Medical Fund
- Tampere University Hospital Medical Fund
- Turku University Hospital Medical Fund
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Foundation of Cardiovascular Research
- Finnish Cultural Foundation
- Sigrid Juselius Foundation
- Yrjo Jahnsson Foundation
- Turku University foundation [11-2259]
- Emil Aaltonen Foundation
- Urmas Pekkala Foundation
- Specialized Center of Research (SCOR) in Atherosclerosis grant from the NHLBI [HL-14230]
- General Clinical Research Centers Program, NCRR, NIH [RR-00059]
- NHLBI [R01 HL-48050, R01 HL-54730, R01 HL-61857]
- Research Council of Lithuania [LIG-01/2012]
Childhood blood pressure (BP) levels predict adult subclinical atherosclerosis. However, the best childhood BP component for prediction has not been determined. This study comprised 5925 participants aged 3 to 18 years from 6 cohorts who were followed into adulthood (mean follow-up 25.8 +/- 6.2 years). Childhood BP was measured by using a standard mercury sphygmomanometer in all cohorts. Study-specific carotid intima-media thickness 90th percentile was used to define subclinical atherosclerosis. Per SD change in the predictor, childhood systolic BP (SBP; age- and sex-adjusted odds ratio [95% CI], 1.24 [1.13-1.37]), mean arterial pressure (1.10 [1.07-1.13]), and pulse pressure (1.15 [1.05-1.27]) were associated with increased adulthood intima-media thickness. In age- and sex-adjusted analyses, area under the receiver operating characteristic curves for SBP (C value [95% CI], 0.677 [0.657-0.704]) showed significantly improved prediction compared with diastolic BP (0.669 [0.646-0.693], P=0.006) or mean arterial pressure (0.674 [0.653-0.699], P=0.01). Pulse pressure provided a C value that was not different from SBP (0.676 [0.653-0.699], P=0.16). Combining different BP components did not improve prediction over SBP measurement alone. Based on the associations with adult carotid intima-media thickness, cut points for elevated SBP were 105 mmHg for 3- to 6-year-old boys, 108 mmHg for 3- to 6-year-old girls, 108 mmHg for 7- to 12-year-old boys, 106 mmHg for 7- to 12-year-old girls, 123 mmHg for 13- to 18-year-old boys, and 115 mmHg for 13- to 18-year-old girls. Our analyses suggest that several childhood BP measurement components are related to adulthood carotid intima-media thickness. Of these, SBP provided the best predictive ability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据