期刊
HUMAN IMMUNOLOGY
卷 80, 期 5, 页码 318-324出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2019.02.014
关键词
Aminopeptidase; Genetic alterations; Antigen processing; Cancer; Transcription factors
类别
资金
- Italian Ministry of Health [PE-2011-02351866]
- Associazione Italiana Ricerca sul Cancro (AIRC) [18495]
The endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 are two multifunctional enzymes playing an important role in the biological processes requiring trimming of substrates, including the generation of major histocompatibility complex (MHC) class I binding peptides. In the absence of ERAP enzymes, the cells exhibit a different pool of peptides on their surface which can promote both NK and CD8(+) T cell-mediated immune responses. The expression of ERAP1 and ERAP2 is frequently altered in tumors, as compared to their normal counterparts, but how this affects tumor growth and anti-tumor immune responses has been little investigated. This review will provide an overview of current knowledge on transcriptional and post-transcriptional regulations of ERAP enzymes, and will discuss the contribution of recent studies to our understanding of ERAP1 and ERAP2 role in cancer immunity.
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