期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 41, 期 4, 页码 1096-1103出版社
WILEY
DOI: 10.1002/hed.25594
关键词
oropharyngeal squamous cell carcinoma; volumetric-modulated arc therapy; step-and-shoot intensity-modulate radiation therapy; acute radiation induced toxicity; radiation therapy
资金
- Philips Medical System
Background To evaluate plan quality using volumetric-modulated arc therapy (VMAT) and step-and-shoot intensity-modulated radiation therapy (SS-IMRT) techniques and for patients treated for oropharyngeal squamous cell carcinoma (OPSCC). Methods Treatment plans for patients treated definitively for stages I-IVb, OPSCC between December 2009 and August 2015 were retrospectively reviewed. Dosimetric endpoints of involved organs-at-risk (OARs) were retrieved from clinical plans. Common Terminology Criteria for Adverse Events scores of acute toxicities were compared. Results Two-hundred twenty-two patients were identified with 134 and 88 receiving SS-IMRT and VMAT with median follow-up time of 23.0 and 7.9 months, respectively. The dosimetric endpoints of the OARs were significantly improved in VMAT cohort, which translated into significantly lower rates of grade 2 or higher acute dysphagia and xerostomia. Conclusion Improvements in stages I-IVb, oropharyngeal cancer plan quality are associated with reduced grade >= 2 acute dysphagia and xerostomia.
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