期刊
GYNECOLOGICAL ENDOCRINOLOGY
卷 35, 期 7, 页码 635-637出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2018.1563889
关键词
YKL-40; pregnancy; cholestasis; inflammation; liver
Intrahepatic cholestasis of pregnancy is a diagnosis of exclusion and presents with unexplained pruritus, abnormal liver function tests, and increased serum bile acid levels, particularly in the third trimester of pregnancy. Serum YKL-40 levels are increased in liver diseases and our aim was to investigate YKL-40 levels in pregnant women with ICP. 40 women with intrahepatic cholestasis of pregnancy and 40 healthy pregnant women were included in this cross-sectional study. Serum YKL-40 levels were measured in both groups and correlation analysis were performed between the YKL-40 and other liver function tests. Serum YKL-40 concentrations were higher in the intrahepatic cholestasis of pregnancy group than in the control group (103.4653.03 vs. 57.6030.30ng/ml, p=.002). The cutoff YKL-40 serum concentration was 84.80ng/ml for the diagnosis of intrahepatic cholestasis of pregnancy. There was no correlation between fasting bile acids and YKL-40 levels. However, there was a significant positive correlation between the YKL-40 levels and aspartate aminotransferase (r=0.22, p=.04) and alanine aminotransferase (r=0.24, p=.02). Raised YKL-40 levels might support the evidence on inflammatory processes in intrahepatic cholestasis of pregnancy.
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