Frailty as a predictor of future falls in hospitalized patients: A systematic review and meta-analysis

The aims of this review were to identify prospective studies examining associations between frailty and falls and to combine the risk measures to synthesize pooled evidence on frailty as a predictor of falls. A systematic literature search was conducted through Embase, Scopus, PubMed, CINAHL Plus, and the Cochrane Library for studies published from inception through May 2018. Odds ratios (OR) and hazard ratios (HR) extracted from the studies were combined to synthesize pooled effect measures using random-effects or fixed-effects models. Six studies involving 3881 hospitalized patients were included in this study. Frailty was found to be significantly associated with future falls among three studies with OR (pooled OR = 1.323, 95%confidence interval = 1.137-1.538, P < 0.000) and three studies with HR (pooled OR = 1.890, 95%confidence interval = 1.456-2.453, P < 0.000). Frailty was a significant predictor of future falls in hospitalized patients. Paying more attention to frailty may lead to lowering fall risks. (C) 2019 Published by Elsevier Inc.