期刊
GENES CHROMOSOMES & CANCER
卷 58, 期 7, 页码 484-499出版社
WILEY
DOI: 10.1002/gcc.22731
关键词
breast cancer; cancer stem cells; epithelial to mesenchymal transition; higher order chromatin organization; hormone regulation; mitotic bookmarking; RUNX
资金
- American Cancer Society [033807, 14-196-01]
- National Cancer Institute [1F32 CA220935, P01 CA082834, U01 CA196383, 1F32CA236125, 1U54CA217297]
- National Institute of Dental and Craniofacial Research [R56 DE012528]
- Charlotte Perelman Fund for Cancer Research
- Pediatric Cancer Research Foundation
- National Institute of General Medical Sciences [R01GM129338]
Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this review, we present a strategic overview of epigenetic regulatory mechanisms including histone modifications and higher order chromatin organization (HCO) that are perturbed in breast cancer onset and progression. Implications for dysfunctions that occur in hormone regulation, cell cycle control, and mitotic bookmarking in breast cancer are considered, with an emphasis on epithelial-to-mesenchymal transition and cancer stem cell activities. The architectural organization of regulatory machinery is addressed within the contexts of translating cancer-compromised genomic organization to advances in breast cancer risk assessment, diagnosis, prognosis, and identification of novel therapeutic targets with high specificity and minimal off target effects.
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